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​Long-term Medical Comorbidities and Functional Decline following TBI

Long-term Medical Comorbidities and Functional Decline following TBI

PI(s): Lead – Flora Hammond, MD and James Malec, PhD (Indiana University/Rehabilitation Hospital of Indiana, Indianapolis, IN); Site – Gale Whiteneck PhD
Funded by: National Institute on Disability and Rehabilitation Research
Dates: 2013 - 2017
Contact(s): Gale Whiteneck (

This module is designed to determine the prevalence and nature of medical and psychiatric complications present years after TBI, and their association with functional decline. The hypothesis is: Among a cohort of individuals who experienced TBI at least 10 years previously, functional decline over time is associated with the prevalence and type of medical and psychiatric conditions present. The proposed interview will be cognitively tested on 10-20 cases. The main study will add co-morbidity questions to the year 10 Form II on 400 cases. These questions include “Has a doctor ever told you had”….20 medical co-morbidities (9 from the current NDB and 11 more from the NHANES national survey), a screener question “Has a doctor or mental health professional ever diagnosed you with a mental health condition, followed by 20 specific mental health diagnoses if the screener was positive. A positive response to any of the 40 co-morbidities triggers follow-up to determine when they were first told of the condition and whether it was before or after their incident TBI. Follow-up to mental health conditions ask whether the person received inpatient or outpatient services for the condition. The primary analytic plan will employ individual growth curve analyses to generate expected trajectories of function predicted by the presence of co-morbidities.